Typed, reproducible high-content microscopy workflows across GUI, Python, CellProfiler, Napari/Fiji, GPU, and local MCP agents.
https://openhcsdev.github.io/openhcs/ ↗// readme
Turn high-content microscopy images into reproducible measurements
One reviewable workflow across the GUI, Python, CellProfiler, and local agents
OpenHCS is designed for imaging scientists and research software teams running high-content studies where many wells, sites, channels, Z planes, or time points must be analysed consistently. Source selection, processing steps, and result definitions stay together in one validated pipeline instead of being split across interface-only state, scripts, and automation.
It is a good fit when a workflow must remain reviewable across visual editing,
code, and automation. The same pipeline can be edited in the desktop GUI or as
Python, imported from supported CellProfiler .cppipe files, and built or
reviewed through the local MCP surface.
Install
Windows installer · macOS installer · Installation options
The graphical installers set up an isolated CPU-safe desktop environment with…